DOI: https://doi.org/10.30978/HV201811021

Протективний вплив альфа-ліпоєвої кислоти на серцево-судинні захворювання, зумовлені оксидативним стресом

L. V. Zhuravlyova, N. A. Lopina

Анотація


Стаття присвячена розгляду протективних властивостей альфа-ліпоєвої кислоти в пацієнтів кардіологічного профілю, зокрема із супутнім цукровим діабетом 2 типу, які становлять групу високого й дуже високого серцево-судинного ризику. Досить докладно розглянуті сучасні патогенетичні механізми ушкодження судинної стінки при дисфункції ендотелію, оксидативному стресі в пацієнтів із серцево-судинною патологією, зокрема із супутнім цукровим діабетом 2 типу. Особливу увагу приділено ролі патогенетично обґрунтованої терапії із застосуванням альфа-ліпоєвої кислоти, що має широкий спектр ­плейотропних ефектів і впливає на показники оксидативного стресу, атерогенну дисліпідемію та ендотеліальну дисфункцію, запалення, атеросклероз. Систематично, спираючись на дані доказової медицини, викладено особливості впливу альфа-ліпоєвої кислоти на метаболічні процеси в організмі, її роль у системі антиоксидантного захисту, а також її цитопротективні властивості, що обґрунтовують раціональність застосування альфа-ліпоєвої кислоти в пацієнтів кардіологічного профілю.


Ключові слова


альфа-ліпоєва кислота; біохімічна дія; серцево-судинні захворювання; цукровий діабет; ендотеліальна дисфункція; оксидативний стрес

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Посилання


Журавлёва ЛВ, Лопина НА. Влияние комбинированной терапии с применением альфа-липоевой кислоты на показатели липидного обмена у больных ишемической болезнью сердца и сахарным диабетом 2 типа. Терапевтический вестник Узбекистана. 2017;4:26-33.

Журавлёва ЛВ, Лопина НА. Влияние комбинированной терапии с применением альфа-липоевой кислоты на показатели поражения сосудов у больных ишемической болезнью сердца. Серце і судини. 2017;4 (60):78-85.

Ansar H, Mazloom Z, Kazemi F. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Medical Journal. 2011;32:584-588.

Ardehali H, Sabbah HN, Burke MA. Targeting myocardial substrate metabolism in heart failure: potential for new therapies. European Journal of Heart Failure. 2012;14 (2):120-129.

Assar ME, Angulo J, Vallejo S et al Mechanisms involved in the aginginduced vascular dysfunction. Frontiers in Physiology. 2012;3 (article ID 132):1-13.

Bayeva M, Gheorghiade M, Ardehali H. Mitochondria as a therapeutic target in heart failure. Journal of the American College of Cardiology. 2013;61 (6):599-610.

Bhatt SR, Lokhandwala MF, Banday AA. Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B. Clinical and Experimental Hypertension. 2014;36 (6):367-373.

Butler AE, Janson J, Bonner-Weir S. Beta-cell deficit and increased betacell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-110.

Cavieres V, Valdes K, Moreno B et al. Vascular hypercontractility and endothelial dysfunction before development of atherosclerosis in moderate dyslipidemia: role for nitric oxide and interleukin-6. American Journal of Cardiovascular Disease. 2014;4 (3):114-122.

Chang JW, Lee EK, Kim TH. Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. American Journal of Nephrology. 2007;27:70-74.

Deng C, Sun Z, Tong G. Alpha lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway. PLoS ONE. 2013;8 (3). Article ID e58371.

Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. BioMed Research International. 2014:1-11.

Dudek M, Knutelska J, Bednarski M. Alpha lipoic acid protects the heart againstmyocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts. Pharmacological Reports. 2014;66 (3):499-504.

Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Seminars in Cardiothoracic and Vascular Anesthesia. 2012;16 (3):123-132.

Gianturco V, Bellomo A. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?. Archives of Gerontology and Geriatrics. 2009;49 (1):129-133.

Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid. Frontiers in Pharmacology. 2011;2:69.

Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetology & Metabolic Syndrome. 2014;6 (1):80.

Hafstad AD, Nabeebaccus AA, Shah AM. Novel aspects of ROS signalling in heart failure. Basic Research in Cardiology. 2013;108 (4). Article 359.

Hamilton SJ, Chew GT, Watts GF. Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus. Diabetes and Vascular Disease Research. 2007;4:89-102.

Harding SV, Rideout TC, Jones PJ. Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk. Journal of Dietary Supplements. 2012;9 (2):116-127.

He L, Liu B, Dai Z et al. Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. European Journal of Pharmacology. 2012;678 (1-3):32-38.

Hegazy SK. Alpha-Lipoic Acid Improves Subclinical Left Ventricular Dysfunction in Asymptomatic Patients with Type 1 Diabetes. The Review of Diabetic Studies. 2013;10 (1):58-67.

Heinisch BB, Francesconi M, Mittermayer F. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. European Journal of Clinical Investigation. 2010;40:148-154.

Kahn BB, Alquieret T. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism. 2005;1:15-25.

Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006;5:251-258.

Kim DC, Jun DW, Jang EC. Lipoic acid prevents the changes of intracellular lipid partitioning by free fatty acid. Gut and Liver. 2013;7 (2):221-227.

Kim HS, Kim HJ, Park KG. Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity. Experimental and Molecular Medicine. 2007;39:106-113.

Kim MS, Park JY, Namkoong C, Jang PG. Antiobesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nature Medicine. 2004;10:727-733.

Kleniewska P, Piechota-Polanczyk A, Michalski L. Influence of block of NF-kappa B signaling pathway on oxidative stress in the liver homogenates. Oxidative Medicine and Cellular Longevity. 2013;Article ID 308358:8 p.

Koh EH, Lee WJ, Lee SA. Effects of alpha-lipoic acid on body weight in obese subjects. American Journal of Medicine. 2011;124:851-858.

Kola B, Boscaro M, Rutter GA, Grossman AB. Expanding role of AMPK in endocrinology. Trends in Endocrinology and Metabolism. 2006;17:205-215.

Krzyzanowska K, Mittermayer F, Krugluger W. Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes. Atherosclerosis. 2006;189:236-240.

Krzyzanowska K, Mittermayer F, Shnawa N, Hofer M. Asymmetrical dimethylarginineis related to renal function, chronic inflammation and macroangiopathy in patients with type 2 diabetes and albuminuria. Diabetic Medicine. 2007;24:81-86.

Lee HA, Hughes DA. Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA. Experimental Gerontology. 2002;37 (2-3):401-410.

Lee JE, Yi Ch., Jeon BT, Shin HJ, Kim SK. Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats. Cardiovascular Diabetology. 2012;11:111.

Lee SJ, Jeong SJ, Lee YC et al. Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea. Diabetes and Metabolism Journal. 2017;41 (4):275-283. doi: 10.4093/dmj.2017.41.4.275.

Lee WJ, Lee IK, Kimet HS. Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:2488-2494.

Lee WJ, Song KH, Koh EH. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochemical and Biophysical Research Communications. 2005;332:885-891.

Li C.-J., Lv L, Li H, Yu D.-M. Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid. Cardiovascular Diabetology. 2012;11. Article 73.

Lim SY, Bae EH. The effect of alpha lipoic acid in a porcine in-stent restenosis model. Journal of Cardiology. 2009;54 (3):375-385.

Madamanchi NR, Runge MS. Redox signaling in cardiovascular health and disease. Free Radical Biology and Medicine. 2013;61:473-501.

Mangge H, Becker K, Fuchs D, Gostner JM. Antioxidants, inflammation and cardiovascular disease. World Journal of Cardiology. 2014;6 (6):462-477.

Maritim AC, Sanders RA. Diabetes, oxidative stress, and antioxidants. Journal of Biochemical and Molecular Toxicology. 2003;17:24-38.

McCarty MF, Barroso-Aranda J, Contreras F. The ‘‘rejuvenatory» impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-c coactivator-1a. Medical Hypotheses. 2008;doi:10.1016/j.mehy.2008.07.043.

Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochimica et Biophysica Acta. 2015;1852 (2):243-251.

Minokoshi Y, Alquier T, Furukawa N. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004;428:569-574.

Mittermayer F, Pleiner J, Francesconi M, Wolzt M. Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus. Translational Research. 2010;155:6-9.

Morcos M, Borcea V, Isermann B, Gehrke S. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Research and Clinical Practice. 2001;52:175-183.

Moreau R. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Archives of Biochemistry and Biophysics. 2009;485 (1):63-71.

Oliveira AM, Rondó PH, Luzia LA. The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, doubleblind, placebo-controlled trial. Diabetes Research and Clinical Practice. 2011;92:253-260.

Padmalayam I. Targeting mitochondrial oxidative stress through Lipoic acid synthase: a novel strategy to manage diabetic cardiovascular disease. Cardiovascular and Hematological Agents in Medicinal Chemistry. 2012;10 (3):223-233.

Parente E, Colannino G, Picconi O, Monastra G. Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study. European Review for Medical and Pharmacological Sciences. 2017;21:4219-4227.

Poh ZX, Goh KP. A Current Update on the Use of Alpha Lipoic Acid in the Management of Type 2 Diabetes Mellitus. Endocrine, Metabolic and Immune Disorders — Drug Targets. 2009;9:392-398.

Porasuphatana S, Suddee S, Nartnampong A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha lipoic acid: a randomized double-blinded placebo controlled study. Asia Pacific Journal of Clinical Nutrition. 2012;21 (1):12-21.

Rahman ST, Merchant N, Haque T, Wahi J. The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. Journal of Cardiovascular Pharmacology and Therapeutics. 2012;17 (2):139-145.

Reriani MK, Dunlay SM, Gupta B. Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-analysis of randomized controlled trials. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. 2011;18:704-716.

Rochette L, Ghibu S, Richard C et al. Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential. Molecular Nutrition and Food Research. 2013;57 (1):114-125.

Rodrigo R, Libuy M, Feliu F, Hasson D. Oxidative stress related biomarkers in essential hypertension and ischemia reperfusion myocardial damage. Disease Markers. 2013;35 (6):773-790.

Rouchette L, Ghibu S, Richard C, Zeller M, Cottin Y, Vergely C. Direct and indirect antioxidant properties of α -lipoic acid. Mol Nutr Food Res. 2013;57:114-125.

Sadowska-Bartosz I, Bartosz G. Effect of antioxidants supplementation on aging and longevity. BioMed Research International. 2014;Article ID 404680:17.

Sawyer DB. Oxidative stress in heart failure: what are we missing?. The American Journal of the Medical Sciences. 2011;342 (2):120-124.

Shay KP, Moreau RF, Smith EJ et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta. 2009;1790:1149-1160.

Singh U, Jialal I. Alpha-lipoic acid supplementation and diabetes. Nutrition Reviews. 2008;66:646-657.

Skibska B, Goraca A. The Protective Effect of Lipoic Acid on Selected Cardiovascular Diseases Caused by Age-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015;2015. P. ID 313021, 11 pages.

Sola S, Mir MQ, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation. 2005;111:343-348.

Standards of medical care in diabetes — 2016. American Diabetes Association. Diabetes Care. 2016;39 (1). P. S.1-S.109.

Steyers C, Miller F. Endothelial dysfunction in chronic inflammatory diseases. International Journal of Molecular Sciences. 2014;15 (7):11324-11349.

Subramanian S, Kalyanaraman B, Migrino RQ. Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. Recent Patents on Cardiovascular Drug Discovery. 2010;5 (1):54-65.

Szelag M, Mikulski D, Molski M. Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites. J Mol Model. 2012;18:2907-2916.

Tarnow L, Hovind P, Teerlink T. Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes. Diabetes Care. 2004;27:765-769.

Venkataraman K, Khurana S, Tai TC. Oxidative stress in aging-matters of the heart and mind. International Journal of Molecular Sciences. 2013;14 (9):17897-17925.

Wojciechowska C, Romuk E, Tomasik A. Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy. Mediators of Inflammation. 2014;ID147040:10.

Wollin SD, Wang Y, Kubow S, Jones PJ. Effects of a medium chain triglyceride oil mixture and alpha-lipoic acid diet on body composition, antioxidant status, and plasma lipid levels in the Golden Syrian hamster. The Journal of Nutritional Biochemistry. 2004;15 (7):402-410.

Wray DW, Nishyyama SK, Harris RA, Zhao J. Acute reversal of endothelial dysfunction in the elderly following antioxidant consumption. Hypertension. 2012;59:818-824.

Xiang GG. Xiang, J. Pu, L. Yue. et al. Alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Metabolism. 2011;60 (4):480-485.

Xiang GD, Sun HL, Zhao LS. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycemia during OGTT in impaired glucose tolerance. Clinical Endocrinology (Oxford). 2008;68:716-723.

Xu J, Yang W, Deng Q. Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet. Lipids in Health and Disease. 2012;11:148.

Yi X, Maeda N. Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apoliprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes. 2006;55:2238-2244.

Yi X, Xu L, Hiller S. Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient mice. Atherosclerosis. 2012;223 (1):137-143.

Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S. Evidence that α-lipoic acid inhibits NFκ-B activation independent of its antioxidant function. Inflammation Research. 2011;60:219-225.

Zhang Y, Han P, Wu N. Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring). 2011;19:1647-1653.

Zulkhairi A, Zaiton Z, Jamaluddin M. Alpha lipoic acid possess dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand White rabbit. Biomedicine and Pharmacotherapy. 2008:62 (10):716-722.




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